Discovery of a novel exceptionally potent and orally active Nur77

nuri77The mechanism of Nur77 regulating cell survival and apoptosis in CNS. Nur77 mediates cell apoptosis through caspase, endoplasmic reticulum stress, and mitochondrial autophagy, whileNur77-GFP reporter mice as a useful tool study Nur77 promoter activity during renal IRI. (A) Induction of GFP transcript level mirrored that of Nur77 in the kidney tissues 24 hours after IRI,